HNRNPC and renal cell carcinoma: The impact of HNRNPC on the interaction of circZBTB44 and IGF2BP3 was further explored, and HNRNPC deficiency evidently decreased the enrichment of IGF2BP3 in the complex of Bio-circZBTB44, suggesting that HNRNPC silencing inhibited the interaction between circZBTB44 and IGF2BP3 in RCC cells (Fig. 4F).