HNRNPC and renal cell carcinoma: The results of MeRIP assays demonstrated that circZBTB44 was significantly enriched in the precipitates of anti-m6A, which was reduced after silencing HNRNPC, and showed no evident change after IGF2BP3 knockdown in RCC cells, suggesting that HNRNPC affected the m6A modification of circZBTB44 (Fig. 4B).