The results of MeRIP assays demonstrated that circZBTB44 was significantly enriched in the precipitates of anti-m6A, which was reduced after silencing HNRNPC, and showed no evident change after IGF2BP3 knockdown in RCC cells, suggesting that HNRNPC affected the m6A modification of circZBTB44 (Fig. 4B). The gene discussed is IGF2BP3; the disease is renal cell carcinoma.