Patients with disseminated TB showed significantly lower CD4 cell counts compared with those with localized form of TB in the lymph nodes [61].These results provided further support for the hypothesis that unlike disseminated TB which is characterized by lower values of peripheral blood immunohematological parameters relative to the PTB, TBLN in Ethiopian could be characterized as a unique form of TB, with higher mean values of WBC and CD4 + T cell counts relative to PTB. This evidence concerns the gene CD4 and tuberculosis.