Taking this background into account, the aim of the present study was to determine the expression pattern of BMP8A in the liver of different preclinical models of hepatic fibrosis and to assess whether serum BMP8A levels could be a good predictor of liver fibrosis stage in patients with NASH, the commonest cause of CLD worldwide. Here, BMP8A is linked to congenital secretory chloride diarrhea 1.