The network pharmacology analysis demonstrated that GQD standard decoction mainly interferes with the occurence and development of CID through the inflammatory and apoptosis signaling pathways, such as PI3K/AKT, Ras, EGFR and NF-κB signaling pathway, which is intimately related to CID pathogenesis [39, 40]. Here, NFKB1 is linked to combined immunodeficiency.