And the alkaloids such as berberine, palmatine, coptisine of Coptis chinensis has been widely demonstrated for treating gastrointestinal diseases, its anti-inflammatory effects involved in MAPK, NF-κB, and PPAR-γ signaling pathway regulation are highlighted in the treatment of gastrointestinal disorders [7]. The gene discussed is NFKB1; the disease is digestive system disorder.