We found that pregnancy affected many MS-associated genes, including for example CXCL10,IL17A, STAT3 and the T cell activation marker CD69. Simultaneously, the rebound modules were also significantly enriched in genes associated with our in vitro T cell activation, which is consistent with previous studies showing that MS is associated with a dysregulation in response to activation in CD4+ T cells [34, 35]. This evidence concerns the gene CD69 and myeloid sarcoma.