SPOP and posterior cortical atrophy: The comprehensive molecular alteration landscape of PCa has been elucidated, and many pivotal mutant genes have been identified, such as ERG, ETV1/4, FLI1, SPOP, FOXA1 and IDH1; however, prior studies are still insufficient to cover all patients with PCa, and nearly 26% of available PCa tissue samples require further study to investigate their gene signatures [26].