BRCA1 and neoplasm: Analysis of RS1 to RS6 revealed that (1) all six RSs occurred at ≥4% in every tumor among early SVs; (2) the frequencies of RS4 or RS5 (characterized by <100-kb deletions and enriched in BRCA1/2-deficient breast tumors26) increased among intermediate (versus early) SVs; and (3) the frequencies of RS2 increased among late SVs (Fig. 3c and Extended Data Fig. 4a).