SCN11A and neoplasm: We then devised a strategy to identify tumor-cell-enriched signatures by detecting differential gene sets (DGSs) and differentially expressed genes (DEGs), where DGSs and DEGs of organ-specific metastasis are (1) depleted bioinformatically of NAN DGSs and DEGs across case-matched, cross-organ, pair-wise comparisons and (2) consistent across multiple such comparisons in ≥3 cases (Fig. 4b and Extended Data Fig. 5b).