Given the role of IGF-1 as a risk factor for BC recurrences, we aimed this study to investigate the association between insulin resistance and MetS risk factors with IGF-1 circulating levels in women with and without MetS (noMetS) from a cohort of BC survivors enrolled in the DIet and ANdrogen-5 (DIANA-5) study (Villarini et al. 2012). This evidence concerns the gene IGF1 and metabolic syndrome.