The model estimated an average IGF-1 decrease of 1.31 ng/mL (95% CI; − 1.96 to − 0.65 ng/mL) in MetS group and 0.84 ng/mL (95% CI; − 1.46 to − 0.20 ng/mL) in noMetS group for each unit of waist circumference. The gene discussed is IGF1; the disease is metabolic syndrome.