IFNG and breast cancer: Through application of ImogiMap on RNA expression data from the TCGA basal-like breast cancer cohort (N = 172 patients) (TCGA, 2012), among 44 T-cell dysfunction signature, 29 immune checkpoints, and additional 20 genes that correspond to receptors or ligands of ICPs in CellPhoneDB database, we identified the significant, specific, and robust interactions that co-associate with IFNG gene expression (Fig. 3a–c and Supplementary Fig. 3, Supplementary Tables 1 and 5).