In addition, quantitative RT-PCR for TYMS demonstrated a 300 to 9000-fold upregulation of TYMS expression in spleen and lymph nodes isolated from hTS/Ink4a/Arf−/− as compared to Ink4a/Arf−/− tumor bearing mice (P < 0.05) (Fig. 2D). The gene discussed is APCDD1; the disease is neoplasm.