Since we observed that TYMS overexpression in Ink4a/Arf−/− mice increased the incidence of soft tissue sarcoma and significantly decreased hTS/Ink4a/Arf−/− survival compared to Ink4a/Arf−/− mice, we analyzed TYMS levels in human soft tissue sarcoma. The gene discussed is APCDD1; the disease is soft tissue sarcoma.