SPHKAP and inborn error of immunity: GlnMgs affects the production of ATP5H, NDUFAB1, PFN2, and SPHKAP, which can activate or inhibit the notch signaling pathway, primary immunodeficiency, B cell receptor signal pathway.a ̆Notch and other signaling pathways regulate immune-inflammatory responses, neuron remodeling, and other processes, as well as the onset and progression of AD.