In addition, reconstruction of clonal lineage trees and visualizing persistent S+ Bm cell clones in a circos plot indicated that individual Bm cell clones acquired different Bm cell fates; for example, a given clone was of a CD21+CD27– resting phenotype at month 6 and adopted CD21+CD27+ resting, CD21–CD27+CD71+ or CD21–CD27–FcRL5+ Bm cell phenotype at month 12 post-infection (post-vaccination) (Fig. 6d,e). The gene discussed is CR2; the disease is infection.