Previous studies on the genomic landscape of angiosarcoma have described recurrent somatic mutations of angiogenic signaling pathway genes, including KDR, PTPRB, and PLCG114–18, as well as genes involved in oncogenic signaling pathways such as MAPK, PIK3CA/AKT/mTOR, and TP5319,20. Here, MTOR is linked to angiosarcoma.