Additionally, POLD1 was significantly positively correlated with tumor T stage (Ta: n = 345, T1: n = 112, T2-T4: n = 16), pathological grade (PUNLMP (papillary urothelial neoplasms of low malignant potential): n = 7, low grade: n = 277, high grade: n = 176) and tumor size (<3 cm: n = 283, ≥3 cm: n = 87) in the UROMOL39 cohort (Fig. 1c, d and Supplementary Fig. 1e). This evidence concerns the gene POLD1 and papillary urothelial neoplasm.