Invasive HCC is associated with worse prognoses than nodular HCC, with more pronounced symptoms and/or higher AFP levels.24 PVTT and EHM are among the most robust factors which can predict patient death, and metastasis can involve different sites and is an important clinical manifestation of advanced HCC.10,14-17,25,26 In this study, we observed an independent predictive effect of advanced HCC on Lenvatinib treatment. This evidence concerns the gene AFP and hepatocellular carcinoma.