Subsequently, an analysis was performed for the tumor infiltrating CD8+ fraction in two articles, resulting in no significant change in CD8+ infiltration post-NAC, with a mean difference of 0.40 (95% CI [-0.16, 0.96], p = 0.16) and low heterogeneity (I2 = 0%) [23, 37]. This evidence concerns the gene CD8A and neoplasm.