Classically, tumors have been staged using the TNM system, but recently, the validation of models such as Immunoscore has allowed a more refined evaluation of colorectal cancer patients prognosis, becoming a reference system for establishing clinical outcome by evaluating the density of CD3+CD8+ T lymphocyte infiltration within the tumor and at the invasive margin of the tumor [3]. The gene discussed is CD8A; the disease is neoplasm.