Intriguingly, the apoptotic pathway induced by LHRH-BinBC without the need for toxin internalization may circumvent several obstacles, such as a low tissue penetration rate, cytosol delivery defect, and toxin degradation in lysosomes prior to exerting their cytotoxic effect, making LHRH-BinBC a promising candidate for development as an alternative cancer therapeutic agent. This evidence concerns the gene GNRH1 and cancer.