The vital role of maintaining hemostatic balance is reflected by the correlation of elevated PAI-1 with many diseases and clinical conditions, such as VTE [26], hypertension [27], stroke [28], coronary artery disease (CAD) [29], Alzheimer disease [30], depression [31], type 2 diabetes mellitus (T2DM) [32], and gestational diabetes [33]. The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.