We performed ELISA assays to the cytokines that we noticed altered in the mouse model (Supplemental Figure 5C) and observed that the reduction in COVID-19–related lung pathology in Infected TgcKO mice was also associated with a reduction in the levels of proinflammatory cytokines/chemokines, especially, CCL3, CCL4, CXCL1, and IL-6 (Figure 3K). This evidence concerns the gene CXCL1 and COVID-19.