BCL2 and neoplasm: Previous studies have shown that the targeted (and inhibited) genes are implicated in tumorigenesis and cancer progression, including FOXM1, WNT, Notch1, CDK4-6, SIRT1, and Bcl-2 [77], and observed complete tumor inhibition in orthotopic mouse models of liver cancer, resulting in no observed immunostimulatory activity or toxicity to normal tissues [183].