Recently, Awan and colleagues have studied the harmonious effect of miR-17-92 cluster inhibitors/mimics and circular RNAs on sorafenib-resistant HCC cells to explore potential resistance mechanisms and to identify putative targets for sorafenib-resistant HCC cells using a hybrid Petri-net-based computational model that integrates seven miRNAs belonging to the miR-17-92 cluster and crosstalk between EGFR and IL-6 signaling pathways, which are differentially regulated by these miRNAs. Here, EGFR is linked to hepatocellular carcinoma.