After non-parametric test analysis, the results of activated lymphocytes showed that the percentage of CD16+CD56+CD69+ cells was significantly higher in AT group [1.18 (2.29)] than in HCs group [0.38 (0.44)] (P < 0.05), with no statistical difference from the LT group; The percentages of CD3+HLA-DR+T cells and CD4+HLA-DR+T cells were significantly higher in AT group [2.95 (2.68), 1.41 (1.5)] as well as LT group [2.52 (2.37),1.16 (1.54)] than in HCs group [1.79 (1.61),0.95 (0.81)] (P < 0.05), while AT group with no statistical difference from the LT group. The gene discussed is CD69; the disease is ataxia telangiectasia.