Chen et al. found that fascaplysin led to the inhibition of the transcriptional activity of PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS) cell line Rh30 through inhibiting CDK4, which is consistent with the finding that activation of CDK4 enhances the activity of PAX3-FOXO1. Here, PAX3 is linked to alveolar rhabdomyosarcoma.