Sun et al. found that circular RNA-g-secretase-activating protein (circGSAP) has a suppressive role in the progression of ischemic pulmonary arterial hypertension (IPAH) via upregulation of BMPR2, a key mediator of vascular homeostasis in IPAH [150]. The gene discussed is BMPR2; the disease is idiopathic pulmonary arterial hypertension.