Coconut oil is rich in medium-chain fatty acids, which play a relevant role in obesity management due to their impact on thermogenesis; avocado oil is rich in oleic acids, which show interesting anti-inflammatory potential; and pomegranate oil is the major source of conjugated linolenic acids, with high potential in obesity prevention, due to their capacity to modulate adiponectin and leptin secretion. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.