For gastrointestinal diseases, a gelatin methacrylate/oxidized hyaluronic acid/galactosylated chitosan/Fe(III)@TA@IGF-2 200 hydrogel, loaded with insulin-like growth factor 2 (IGF-2), can regenerate the damaged hepatocytes and improve the survival of the damaged human hepatic stellate LX2 cells. Here, IGF2 is linked to gastrointestinal disease.