Similar to previously published reports (18, 19), aged mice exhibit increased mortality (17% [2/12] versus 0% in sham control and young mouse CLP), worsened acute kidney injury (Fig. 1B), and elevated plasma levels of the inflammatory cytokine interleukin-6 (Fig. 1C) after CLP (additional plasma cytokine data are presented in Fig. S1 in the supplemental material). The gene discussed is IL6; the disease is acute kidney injury.