Within this spectrum, patients with AIH had the highest mean of sCD25, sLAG-3, sCD86, sTim-3, TNF, IFN-γ, IL-6, IL-10, IL-12p70, IL-17A, sCD137 (s4-1BB), and sCTLA-4 levels, whereas PBC samples were characterized by the highest mean IL-2, TGF-β1, and LTA (TNF-β) levels. The gene discussed is TGFB1; the disease is primary biliary cholangitis.