We previously reported a T cell and B cell immune signature of AIH that we found in blood and liver immune cell repertoires by next-generation immunosequencing.17 The signature consisted essentially of a strongly biased T cell receptor beta chain (TRB) V gene usage that was independently found in active AIH but also on complete biochemical response and that differed from immune repertoires of patients with PBC. Here, THRB is linked to autoimmune hepatitis.