In our previous study, we showed biased TRB and IGH V-J gene usage in blood-derived and liver-derived T and B cells in classical AIH or PBC versus HD (with only minor differences between AIH and PBC).17 Likewise, principal component analysis showed skewing of TRB and IGH V-J gene usage in patients with variant syndromes relative to HD (Figure 1B) comparable to that previously observed for classical AIH and PBC.17 Multivariate ANOVA (Pillai-Bartlett trace test) suggested that variant syndromes had repertoire biases that cannot be distinguished from those of classical AIH and PBC (Figure 1B). The gene discussed is THRB; the disease is autoimmune hepatitis.