DYRK1A is a protein kinase implicated in multiple DS phenotypes, which may be acting through several mechanisms (Ahn et al., 2006; Altafaj et al., 2001; Brault et al., 2021; Duchon et al., 2021; Jiang et al., 2015; London et al., 2018; McElyea et al., 2016; Souchet et al., 2014; Thomazeau et al., 2014; Watson-Scales et al., 2018; Yin et al., 2017). This evidence concerns the gene WEE1 and Dravet syndrome.