AKT1 and Dravet syndrome: One of these genes, Dyrk1a, which encodes the DYRK1A serine/threonine protein kinase, has been shown to contribute to several DS phenotypes when present in three copies (Ahn et al., 2006; Altafaj et al., 2001; Brault et al., 2021; Duchon et al., 2021; Jiang et al., 2015; London et al., 2018; McElyea et al., 2016; Souchet et al., 2014; Thomazeau et al., 2014; Watson-Scales et al., 2018; Yin et al., 2017).