However, these cellular aggregates were not observed in mice with a germline mesenchymal Gαq/11 knockout, and it was not possible to fully define the role of inflammation and the immune response in the emphysema observed in Pdgfrb-Cre/ERT2+/−;Gnaqfl/fl;Gna11−/− mice in our study. This evidence concerns the gene PDGFRB and pulmonary emphysema.