Given that there were some similarities in appearance of the abnormal peripheral pulmonary vasculature in Pdgfrb-Cre+/−;Gnaqfl/fl;Gna11−/− lungs to those seen in pulmonary arterial hypertension, we assessed the hearts from these animals for evidence of right ventricular hypertrophy. The gene discussed is PDGFRB; the disease is pulmonary arterial hypertension.