The expression of A2AR was up‐regulated on lymphocytes of patients with ankylosing spondylitis in another study, and agonists of A2AR inhibited the activation of NF‐κB and production of TNF, IL‐1β, IL‐6, MMP‐1, and MMP‐3.56 Here, ADORA2A is linked to ankylosing spondylitis.