The possible mechanism of this effect may be that (1) IL‐6 binds to its receptor IL‐6R and gp130 to further activate multiple signaling pathways (such as the Janus kinase/signal transduction and activator of transcription pathway, mitogen‐activated protein kinase pathway, and phosphatidylinositol 3‐kinase/protein kinase‐B pathway) to promote the development of atherosclerosis and chronic inflammation, which serve as key pathophysiological events for subsequent myocardial infarction and cardiovascular mortality in dialysis patients.43, 44, 45, 46, 47. The gene discussed is IL6R; the disease is myocardial infarction.