The findings of the study pointed to (1) possible immunopathogenetic roles of the immune response genes CLEC12A, IFI27, and CLC in Turkish BS cases, (2) the presence of significant gene expression differences among distinct BS subgroups, (3) divergent roles and variant predominance of the innate and adaptive immune responses in mucocutaneous versus ocular & vascular BS cases, and (4) a loss of potentially important information at the molecular level by examination of distinct BS clinical phenotypes gathered into a single patient group. The gene discussed is IFI27; the disease is Bloom syndrome.