EREG and Bloom syndrome: Additionally, in the same study, four functional gene groups, namely (1) negative regulators of inflammation (CD69, CLEC12A, TNFAIP3), (2) neutrophil granule proteins (LTF, OLFM4, AZU1, MMP8, DEFA4, CAMP), (3) antigen processing and presentation proteins (CTSS, ERAP1), and (4) regulators of immune response (LGALS2, BCL10, ITCH, CEACAM8, CD36, IL8, CCL4, EREG, NFKBIZ, CCR2, CD180, KLRC4, NFAT5) were shown to be potentially instrumental in BS immunopathogenesis.5