The literature harbors many inflammatory/immunological conditions including inflammatory bowel diseases, psoriasis, systemic lupus erythematosus, Sjögren's syndrome, antiphospholipid syndrome, acute graft‐versus‐host disease, immune thrombocytopenic purpura, Aicardi−Goutieres syndrome, Kikuchi−Fujimoto, and hand, foot, and mouth diseases, in which significant increases in IFI27 expression have been reported.39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50. Here, IFI27 is linked to Aicardi-Goutières syndrome.