Taken together with these literature information, our findings regarding decreased expression of CLC in the ocular and vascular BS subgroups may indicate that, in addition to CLEC12A and IFI27, CLC may also be playing a role in (1) the emergence of the characteristic hyperinflammatory manifestations of BS, and (2) the addition of the adaptive immune response to the initial scene of innate immunity in BS, particularly in ocular and vascular cases. Here, IFI27 is linked to Bloom syndrome.