APDS, ALPS, CVID, SIgAD, STAT1 GOF, STAT3 GOF, DGS, IPEX, CTLA‐4 haploinsufficiency and deficiency of LRBA, WAS, dominant‐negative defects in CARD11, ICOS deficiency, PNP deficiency, SCID. The gene discussed is CARD11; the disease is common variable immunodeficiency.