Recurrent otitis media is seen in SIgAD, CVID, XLA, severe combined immunodeficiency (SCID), WAS, defects of complement components (C2, C3, H, I, and P), THI, Ig GSD, PCD, and HIES.17, 20, 21, 32. The gene discussed is C2; the disease is severe combined immunodeficiency.