X‐linked CD40L deficiency (the most common cause of HIGM), sIgAD, STAT3 GOF, Blau Syndrome, APDS, MHC I deficiency, ALPS, DGS, IPEX, WAS, XLA, ICOS deficiency, PNP deficiency, SCID. This evidence concerns the gene ICOS and activated PI3K-delta syndrome.