Intracranial calcifications, cerebral atrophy, and leukodystrophy should alert physicians to spondylo‐enchondro‐dysplasia with immune dysregulation, ADAR1 deficiency, SAMHD1 deficiency, and type 1 interferonopathies.1 The gene discussed is ADAR; the disease is hyperinsulinemic hypoglycemia, familial, 4.