We hypothesized that (I) lipopolysaccharide (LPS)‐stimulated human renal mesangial cells (HRMCs) could be used to establish LN models in vitro; (II) lncRNA TUG1 has a protective effect on LPS‐induced HRMCs; and (III) the potential mechanism of lncRNA TUG1 protection may be linked to the miR‐153‐3p/Bcl‐2 axis. Here, BCL2 is linked to lobular neoplasia.