Our data suggests that LPS treatment gradually inhibited HRMC viability, induced higher numbers of apoptotic cells than those in the control group, reduced Bcl‐2 expression, enhanced Bax level, and promoted the secretion of inflammatory factors, in comparison with the control group, consistent with a previous study24; these findings indicate that the in vitro LN model was established successfully. This evidence concerns the gene BCL2 and lobular neoplasia.