This study has aimed at evaluating the effect of a monoclonal anti‐IL‐4Rα antibody on the total and specific IgE (sIgE) serum levels, the in vitro basophil activation and the T cell allergen proliferation in individuals bearing AD and ARC symptoms and being diagnosed based on the serum allergen sIgE for common birch or timothy grass. The gene discussed is IGHE; the disease is Alzheimer disease.