A very recent human study reported that elevated levels of circulating PDGF‐BB and loss of PDGFβ are associated with cerebrovascular damage specifically in individuals at genetic risk of Alzheimer's disease.[37] It is interesting to test if elevated PDGF‐BB at the conditions of Alzheimer's disease and small vessel disease also induces PDGFRβ shedding through MMP14 or other matrix metalloproteinases. The gene discussed is MMP14; the disease is Alzheimer disease.