ADAM17 and early-onset autosomal dominant Alzheimer disease: It was reported that ADAM10 and ADAM17, members of ADAM family, are involved in PDGFRβ shedding in fibroblasts.[31] Moreover, it has been reported that elevated CSF levels of ADAM17 exist in subjects with mild cognitive impairment and patients with Alzheimer's disease.[48] In our gene array experiment, none of the ADAM family members were upregulated by PDGF‐BB treatment in brain pericytes.