PDGFRB and coronary artery disorder: We previously found that HFD‐challenge mice also had much higher serum PDGF‐BB concentration relative to CHD mice.[20] Similar to age‐associated cerebrovascular phenotype, HFD also causes cerebrovascular impairment[22] and PDGF‐BB/PDGFRβ signaling alteration in the brain.[23] We therefore assessed cerebrovascular changes in mice fed HFD.