The ethanolic extract of Glycyrrhiza glabra (G. glabra) (200 and 300 mg/kg, PO) significantly reduced total cell count and inflammatory cell migration, reduced the W/D weight ratio, reduced the total protein content, reduced the expression of TNF-α, IL-1, and IL-6, improved SOD activity, and significantly protected the lung injury in LPS-induced ALI female mice. The gene discussed is IL1B; the disease is acute respiratory distress syndrome.