Chrysin (CHR) (3 mg/kg, IT) may have therapeutic potential for relieving LPS-induced ALI in mice by blocking the Inositol-requiring enzyme 1/thioredoxin interaction protein/NLRP3 (IRE1/TXNIP/NLRP3) pathway and thus decreasing inflammatory cytokine release. This evidence concerns the gene ERN1 and acute respiratory distress syndrome.