The effect of hordenine (Hor) (10 mg/kg) on LPS-induced ALI inhibited the levels of IL-1β, IL-6, and TNF-α in the BALF and IL-1β, IL-6, iNOS, Cox2, and MPO mRNA expression levels in the lung tissues of ALI mouse model. This evidence concerns the gene PTGS2 and acute respiratory distress syndrome.