Chrysin (CHR) (3 mg/kg, IT) may have therapeutic potential for relieving LPS-induced ALI in mice by blocking the Inositol-requiring enzyme 1/thioredoxin interaction protein/NLRP3 (IRE1/TXNIP/NLRP3) pathway and thus decreasing inflammatory cytokine release. The gene discussed is TXNIP; the disease is acute respiratory distress syndrome.