SNCA and Parkinson disease: Given the known action of some flavonoids as protein mis-folding and aggregation antagonists, it is also tempting to speculate that vitexin could also possess this beneficial property of inhibiting α-synuclein oligomerisation, fibrillisation and Lewy body formation, and could also upregulate UPS and ATGS, which thus confers neuroprotection in PD (Figure 6).