TNFRSF11B and type 2 diabetes mellitus: Finally, LLLT is a promising option to be used in controlled T2DM patients due to its outstanding influence on bone density and estimated crevicular levels of OPG. Therefore, the use of LLLT to promote implant osseointegration needs further in vitro and in vivo studies, which should investigate the mechanisms involved in the desirable and undesirable effects of laser irradiation.