Furthermore, the forelimb grip strength of C57BL/10-mdx mice show 13.0% of reduction from WT mice (Spurney et al., 2009), while DMD nude rats show 36.0% reduction from WT mice at 5-6-month-old.We also observed increased muscle breakdown markers including serum CK activity and urine titin level, in the early stages of disease progression, which decreased as the disease progressed. The gene discussed is TTN; the disease is Duchenne muscular dystrophy.