The gene polymorphisms of IL-10–1082 GA + AA vs. GG (OR = 1.43, 95% CI = 1.12–1.83), IL-10–1082 AA vs. GG (OR = 2.03, 95% CI = 1.36–3.02), IL-18 -137 GG vs. CC (OR = 3.84, 95% CI = 1.29–11.40), TGF-β1 -509 T vs. C (OR = 2.52, 95% CI = 1.42–4.48), and IFN-γ +874 T vs. A (OR = 1.98, 95% CI = 1.32–2.98) were associated with liver cirrhosis significantly and no association was observed in other gene polymorphisms included in the meta‐analysis. This evidence concerns the gene TGFB1 and cirrhosis of liver.