Gene polymorphisms of IL-10–1082 GA + AA vs. GG (OR = 1.43, 95% CI = 1.12–1.83), IL-10–1082 AA vs. GG (OR = 2.03, 95% CI = 1.36–3.02), IL-18 -137 GG vs. CC (OR = 3.84, 95% CI = 1.29–11.40), and TGF-β1 -509 T vs. C (OR = 2.52, 95% CI = 1.42–4.48) were significantly associated with liver cirrhosis. This evidence concerns the gene IL10 and cirrhosis of liver.