The results indicated that gene polymorphisms of CXCL-1 (rs4074G/A), IFR5(rs13242262A/T, rs10488630A/G), IL-13 (rs1800925A/T), IL-17 (rs4711998A/G), IL-1α(rs3783553del/ins), IL-22 (rs1026788A/G, rs1179249A/C, rs2227472A/G, rs2227485C/T, rs2227491A/G), IL-33 (rs1048274A/G, rs10975519T/C, rs4742170T/C), IL-6 (rs10499563T/C, rs2069837A/G), MIF(-173G/C), TNF-α(-857C/T, −863C/A) were risk factors for liver cirrhosis and gene polymorphisms of IFN-γ(+2109A/G, IL-2 (-330T/G), IL-6 (rs1474347A/C), IL-8 (-251A/T) were protective factors for liver cirrhosis. The gene discussed is CXCL1; the disease is cirrhosis of liver.