No significant association of gene polymorphisms of IL-13 (rs20541A/T), IL-17 (rs4711998A/G, rs763780C/T), IL-1α(-889A2A2), IL-1β(-3953A2A2, -31C/T), IL-2 (+114T/G, −384T/G), IL-22 (rs2046068A/C, rs2227473A/G, rs7314777T/C), IL-27 (-964A/G, 2905T/G), IL-28 (rs8099917T/G), IL-4 (-589C/T, −33C/T), IL-6 (rs1800796G/C, rs1800795G/C), IL-8 (+781C/T), IRF3(-925A/G), LT-α(+252A/G), TGF-β1 (-800G/A, Leu10ProC/T), TNFAIP3(rs148314165T/T del, rs200820567T/A, rs2230926G/T), VEGFA (+936C/T) with liver cirrhosis were found. This evidence concerns the gene IRF3 and cirrhosis of liver.