Our results showed that there were no significant associations of IL-10 (-592C/A, −819C/T), IL-18 (-607A/C), IL-1β −511C/T, IL-28 rs12979860C/T, TGF-β1(Arg25ProC/G), TNF-α (−308G/A, −238G/A) with liver cirrhosis. The gene discussed is IL18; the disease is cirrhosis of liver.