Consequently, we aimed to analyze sex-stratified effects of single nucleotide polymorphisms (SNPs) previously identified in GWAS for BMI (Pulit et al., 2019) or AN (Watson et al., 2019) and located in the genomic regions of CKB, CKMT1B, and GATM. Subsequently, we sequenced the coding regions of these genes in children and adolescents with severe obesity and healthy-lean controls. This evidence concerns the gene CKB and Obesity.