The presence of infrequent non-synonymous variants in CKB and CKMT1B (rs146047573, rs758572075, rs1230355611, and rs149544188) was confirmed in independent study groups comprising 781 families with severe obesity, 320 children and adolescents with severe obesity, and 253 healthy lean controls (see Table 2). The gene discussed is CKMT1B; the disease is obesity disorder.