Because AIEgens can monitor and induce apoptosis,they can treatdiseases, especially in developing cancer therapy.5,66−68 As shown in Figure 3A, Bcl-2 antisense oligonucleotides (OSAs), which candecrease expression of the anti-apoptosis protein, were conjugatedonto the surface of TBD-N3 NPs to form lysosome targetedSNA.68 The cell apoptosis assay showedthat AIE NPs induced 21.3% apoptosis cell upon light illumination(Figure 3C). Here, BCL2 is linked to cancer.