CASP3 and neoplasm: Moreover, the decreased mitochondrialmembrane potential and increased concentration of caspase 3 furtherproved that TPA-S-TPP was an apoptosis inducer.67 As illustrated in Figure 3F, compared with the control group, the NIR fluorescencesignal of TPA-S-TPP at the tumor site gradually increased to confirmthe potential of AIEgen for in vivo imaging and phototherapyapplications.