The underlying mechanism, whereby DZSM exerts its ameliorating effect on cognitive deficits appears to be mediated by the regulation of CXCL12/CXCR4, suppression of the expression of inflammatory cytokines, and adjustment of the intestinal flora composition, including Bacteroidia, Erysipelotrichia, and Deferribacteres species. This evidence concerns the gene CXCR4 and Cognitive impairment.