Lack of NR reversal of ammonia‐induced NAD+ deficiency or lower redox ratio may be related to the unaltered nicotinamide riboside kinase 1 (NRK1) during hyperammonemia (as seen on our bioinformatics analyses) or context‐dependent responses to NR reported in skeletal muscle by others (Dollerup et al., 2020). The gene discussed is NMRK1; the disease is Hyperammonemia.