The mechanisms and consequences of reduced redox ratio during hyperammonemia were identified by chemical and genetic methods including the use of nicotinamide riboside (NR) an NAD+ precursor, (Trammell et al., 2016), overexpression of either Lactobacillus brevis NADH oxidase (LbNOX) without/with a mitochondrial localizing sequence (MitoLbNOX) (Titov et al., 2016), or Sirt3 that preferentially localizes to the mitochondria (Parodi‐Rullan et al., 2018). This evidence concerns the gene SIRT3 and Hyperammonemia.