TP53 and Hyperammonemia: Similar to previous reports of increased senescence markers during hyperammonemia in skeletal muscle in preclinical models (Kumar et al., 2021; Welch et al., 2021) and neural tissue (Gorg et al., 2015; Jo et al., 2021), hiPSC‐derived myotubes also demonstrated similar markers including increased expression of P16, P21 and phosphorylated P53 (Figure 5b) showing the translational relevance of these observations.