In line with neuroprotective and neurotrophic functions, as shown in the current work, the efficacy of apigenin in neurodegenerative diseases and depression has also been reported in various animal models, in which the mechanistic action is often linked to an increase of Trk‐mediated signaling, as well as an increase of BDNF level.13 The gene discussed is BDNF; the disease is major depressive disorder.