Allergen-induced asthma of animal models mimicking the major features of human asthma has been reported in several studies to clarify the pathogenesis mechanisms, including immunoglobulin E (IgE) production, airway hyperresponsiveness to methacholine, airway inflammation, inflammatory cell infiltration in bronchoalveolar lavage (BAL) and lung pathology [12]. This evidence concerns the gene IGHE and asthma.