Through the independent tumor tissue database, we analyzed 635 CRC and 681 UC/EC tumor tissue samples with clonal vs subclonal multiple PIK3CAmut against the potential for co-occurring RTK and non-PIK3CA PI3K pathway alterations and observed no differences (data not shown); as alluded to, this may be due to inherent differences in the biologies of these tumor types compared to breast cancer and/or due to an underpowered dataset. Here, PIK3CA is linked to breast cancer.