Except UPF0764 protein and A-gamma globin Osilo variant, 8 of the top 10 down-regulated DEPs have also mentioned in other types of cancers, adhesion G-protein-coupled receptor G1 (decreased) [28], keratin-type I cytoskeletal 16 [27], Huntingtin interacting protein-1 (decreased) [29], ribosomal protein L19 (increased) [30], Beta-1,4-galactosyltransferase 1 (negatively regulates cell survival) [31], trefoil factor 3 (decreased) [32, 33], hemoglobin alpha-2 globin mutant [34], sulfotransferase [35, 36]. Here, KRT16 is linked to cancer.