CHI3L1 and cancer: All 10 of the mostly up-regulated DEPs in this study have already addressed in other types of cancers showing overexpression, i.e., fibronectin 1 [7, 15], chitinase-3-like protein 1 [16, 17], metalloproteinase inhibitor 1 [18, 19], thrombospondin-2 [20, 21], thrombospondin type 1 [22, 23], TNC protein [24, 25], KRT1B protein, dermcidin [26], keratin, type II cytoskeletal 5 [27].