TYR and prostate cancer: In another study, it was reported that the combination of tyrosinase to calcined porous carbon-based ZIF-8 containing the PSA aptamer not only increased the LOD of prostate cancer to 0.01 ng mL− 1 with a wide range of 0.01 to 50 ng mL− 1 but also significantly improves the electrical signal based on the tyrosinase activity to catalyze the oxidation of electro-inactive phenol to electro-active catechol and start the redox cycle under the influence of NADH [77].